【Objective】To investigate the role of microRNA-145/Smad interacting protein 1（SIP 1）in VEGF-C- enhanced cervical cancer metastasis.【Methods】Cervical cancer cell line SiHa cells were cultured and treated with VEGF-C to observe its effect on the expression of miR-145 and SIP1. After transfection with specific SIP1 siRNA，the invasion number of cultured cells were calculated by transwell chamber assay.【Results】Treatment with VEGF-C（100 ng/mL）for 12 h，24 h and 48 h all reduced miR-145 expression，with the expression abundance of（82.4±6.4）% （P<0.05），（72.5±7.2）%（P<0.01），and（60.6±9.6）%（P<0.001），respectively，when compared to control. Meanwhile， the same treatment with VEGF-C also increased SIP1 protein expression，with the expression abundance of（142.4± 16.5）%（P<0.05），（183.6±11.4）%（P<0.01）and（220.8±15.7）%（P<0.001），respectively. The transfection of miR-145 mimic significantly impaired VEGF-C effect on SIP1 expression. Finally ，VEGF-C promoted SiHa cell invasion，which was largely inhibited by the tranfection of SIP siRNA with the inhibitory rate of（56.6±10.3）%（P<0.01）. 【Conclusion】VEGF-C downregulates miR-145，thus increases SIP1 expression and promotes cervical cancer cell invasion，which may contributes to cervical cancer malignant progression.