【Objective】The retrospective study was designed to analyze the dynamic relationship between the Apolipoprotein A1， B100 and the progression of coronary artery lesion.【Methods】Patients who underwent the second coronary angiography or coronary 320-slice CTA at a minimum review interval of 6 months after their first examinations in the Third Affiliated Hospital of Sun Yat-sen University from 2010 to 2015（n = 245），were divided into non progress group（n = 114）and progress group（n = 131）. We compared the differences of clinical and Biochemical data between two groups，and tried to find out the relationship by Logistic Regression analy? sis.【Results】The baseline levels of APOA1（1.33 ± 0.29 vs 1.24 ± 0.25，P = 0.015），APOA1/AOPB100（1.56 ± 0.65 vs 1.38 ± 0.44， P = 0.014）in non progress group were higher than those in progress group. The baseline levels of APOB100 were similar in both groups. The follow-up levels of APOA1 were higher than the baseline levels in both groups，the variation was significant in progress group（1.24 ± 0.25 vs 1.31 ± 0.28，P = 0.006）. The levels of APOA1 and APOA1/APOB100 were correlated with progression of coronary artery le? sion negatively in single-variate logistic regression analysis. The level of APOA1（OR = 0.245，P = 0.005）was correlated with progres? sion of coronary artery lesion negatively in multivariate logistic regression analysis.【Conclusions】APOA1 may has the effect of delay? ing the progression of coronary artery lesion，and may predict the progression of coronary artery lesion.