【Objective】 To explore the influence of UPOINT domains on erectile dysfunction (ED) in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). 【Method】 From January to July 2014

192 CP/CPPS patients were evaluated by UPOINT system. Each patient underwent clinical assessment and answered the questionnaire consisted of socio-demographics

Patient Health Questionnaire (PHQ)

Pain Catastrophizing Scale (PCS)

National Institutes of Health- Chronic Prostatitis Symptom Index (NIH-CPSI) and International Index of Erectile Function (IIEF-5).【Results】 Of 192 CP/CPPS patients

47.4% suffered from ED. The positive rate was U 70.8%

P 59.9%

O 80.7%

I 23.4%

N 45.3% and T 62.5% respectively for each UPOINT domains. Multivariate logistic regression showed UPOINT psychological (P) domain was independent risk factor for ED in CP/CPPS (OR=3.749

95% CI 1.903-7.384

P 0.05). 【Conclusion】The CP/CPPS patients had a higher rate of ED. Psychological factor was independent risk factors of ED in CP/CPPS. Pain

voiding symptoms and local inflammation of the prostate were not. But severe pain and voiding symptoms affected patients’ psychological state

which affected the patient’s erectile function.