Having been modified and improved in the past 40 years，transcatheter arterial chemoembolization（TACE）has  now been widely accepted and recognized as the standard treatment for advanced hepatocellular carcinoma（HCC） by various clinical practice guidelines. In the era of precision medicine，although TACE has been faced with many new challenges，enhancing the effectiveness and security of TACE will be always our core mission. In accordance with the requirements of medical progress，interventionalists should be clear how to improve TACE technique and find more evidence to push the treatment forward.