附属第七医院泌尿外科,广东,深圳,518107
网络首发:2020-09-11,
纸质出版:2020
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江东根, 杨祥伟, 陈楚杰, 等. 前列腺体积对保留神经根治性前列腺切除术的影响及其预测术后控尿恢复价值[J]. 中山大学学报(医学科学版), 2020,41(5).
Effect of Prostate Volume on the Outcomes of Nerve Sparing Laparoscopic Radical Prostatectomy and its Predictive Value for Postoperative Continence Recovery[J]. Journal of Sun Yat-sen University (Medical Sciences), 2020, 41(5).
江东根, 杨祥伟, 陈楚杰, 等. 前列腺体积对保留神经根治性前列腺切除术的影响及其预测术后控尿恢复价值[J]. 中山大学学报(医学科学版), 2020,41(5). DOI:
Effect of Prostate Volume on the Outcomes of Nerve Sparing Laparoscopic Radical Prostatectomy and its Predictive Value for Postoperative Continence Recovery[J]. Journal of Sun Yat-sen University (Medical Sciences), 2020, 41(5). DOI:
【目的】探讨前列腺体积对保留神经腹腔镜下根治性前列腺切除术(nsLRP)结果的影响,并分析其对术后控尿恢复的预测价值。【方法】回顾性分析 2004 年 1 月至 2018 年 6 月 178 例行nsLRP 术低危前列腺癌(PCa)患者的临床资料。所有患者术前控尿功能正常,年龄46~88 岁,平均66 岁;PSA 0.6~10.0 μg/L,中位值6.9 μg/L; 平均体质量指数(24±5)kg/m2。采用Spearman 相关系数分析前列腺体积与围术期资料关系,单因素与多因素Cox回归分析鉴定术后控尿功能恢复的预测因子。【结果】列腺体积增大与高龄(rs=0.370,P<0.001)、PSA 升高(rs= 0.168,P=0.025)、更低穿刺病理 Gleason 评分(rs=-0.165,P=0.027)、更低术后病理 T 分期(rs=-0.152,P=0.042)及 Gleason 评分(rs=-0.182,P=0.015),更长手术时间(rs=0.239,P=0.001),以及更多术中出血量(rs=0.181,P=0.016)密切相关。术后3、6、12 个月时控尿率分别为64.0%(114/178)、88.2%(157/178)和96.1%(171/178)。单因素与多因素Cox 回归分析提示患者年龄(RR=0.528,95% CI:0.381~0.730)与前列腺体积(RR=0.598,95% CI:0.412~0.869) 为术后控尿功能恢复的独立预测因子。【结论】低危PCa 中高龄患者前列腺体积大,大体积前列腺PCa 患者术前PSA 高、肿瘤分级分期低、根治术中出血多、手术时间长。高龄、前列腺体积增大为nsLRP 术后患者不良控尿恢复的独立预测因子。
【Objective】To explore the effect of prostate volume on outcomes of nerve sparing laparoscopic radical prostatectomy(nsLRP)and investigate its predictive value for postoperative continence recovery.【Methods】A retrospective study was conducted on 178 patients with low risk prostate cancer(PCa)who underwent nsLRP from January 2004 to June 2018. All the patients included had normal preoperative urinary function,a mean age of 66 years(range 46~88),a median PSA level of 6.9 μg/L(range 0.6~10.0)and a mean body mass index of(24±5)kg/m2. The correlation of prostate volume with perioperative data was assessed by using Spearman correlation coefficient. Univariate and multivariate Cox regression analyses were employed to identify prognostic predictors for postoperative continence recovery.【Results】Increased prostate volume was significantly correlated with older age(rs=0.370,P<0.001),higher PSA level(rs=0.168, P=0.025),lower biopsy Gleason score(rs=- 0.165,P=0.027),lower pathological T stage(rs=-0.152,P=0.042)and Gleason score(rs=-0.182,P=0.015),longer operative time(rs=0.239,P=0.001)and greater estimated blood loss(rs= 0.181,P=0.016). The continence rates in the 3rd,6th,and 12th month after surgery were 64.0%(114/178),88.2%(157/178),and 96.1%(171/178),respectively. Univariate and multivariate Cox analysis showed that patient age(RR= 0.528,95% CI:0.381~0.730)and prostate volume(RR=0.598,95% CI :0.412~0.869)were independent predictors of continence recovery.【Conclusions】Larger prostate volume was associated with older age,higher PSA level,lower tumor stage and grade,greater intraoperative blood loss and longer operative time in low risk PCa patients. Older age and in⁃ creased prostate volume may independently predict poor continence recovery after nsLRP.
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