1.中山大学孙逸仙纪念医院输血科,广东 广州510000
2.深圳平乐骨伤科医院检验科,广东 深圳518000
李楠,硕士生,技师,研究方向:输血免疫,E-mail: 625016813@qq.com
纸质出版日期:2023-03-20,
收稿日期:2022-09-21,
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李楠,张怡宇,谢双锋等.C反应蛋白和嗜酸性粒细胞百分比在青年输血不良反应危险因素分析中的作用[J].中山大学学报(医学科学版),2023,44(02):335-341.
LI Nan,ZHANG Yi-yu,XIE Shuang-feng,et al.The Role of EO% and CRP in Risk Factors Analysis of Young Patients with Transfusion Related Adverse Reactions[J].Journal of Sun Yat-sen University(Medical Sciences),2023,44(02):335-341.
李楠,张怡宇,谢双锋等.C反应蛋白和嗜酸性粒细胞百分比在青年输血不良反应危险因素分析中的作用[J].中山大学学报(医学科学版),2023,44(02):335-341. DOI: 10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2023.0219.
LI Nan,ZHANG Yi-yu,XIE Shuang-feng,et al.The Role of EO% and CRP in Risk Factors Analysis of Young Patients with Transfusion Related Adverse Reactions[J].Journal of Sun Yat-sen University(Medical Sciences),2023,44(02):335-341. DOI: 10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2023.0219.
目的
2
探讨青年患者发生输血不良事件的危险因素及与外周血C反应蛋白(CRP)及嗜酸性粒细胞百分比(EO%)的关系。
方法
2
收集2019年1月-2020年12月发生输血不良反应的66例青年患者资料,做为观察组;对照组则随机选取未发生输血反应,且入院年月、科室、疾病、血制品类型、性别与观察组分别对应的66例青年患者。分析两组患者年龄、输血史、过敏史、输血前静脉血CRP及EO%水平,绘制受试者工作特征(ROC)曲线评价输血前静脉血CRP与EO%对输血不良反应预测的效能,并使用回归分析对危险因素进一步验证。
结果
2
与对照组患者相比,观察组发生非溶血性发热反应(FNHTR)患者输血前CRP更高;观察组发生过敏性输血反应(ATR)患者输血前CRP更高,有输血史者占比更高,输血前EO%更低,差异有统计学意义(
P
<0. 05)。输入不同血液品种对发生ATR和FNHTR具有差异性(
P
<0. 05)。输血前CRP对诊断 FNHTR的ROC曲线下面积0.889,最佳截断值18.05 mg/L(
P
<0. 05);输血前CRP对诊断 ATR 的ROC 曲线下面积0.749,最佳截断值为17.6 mg/L(
P
<0. 05)。
结论
2
输血前C反应蛋白水平是青年患者发生 FNHTR和ATR的独立危险因素,对输血不良反应的发生具有诊断价值;EO%对输血不良反应的预测价值不足。
Objective
2
To discuss the correlation between young patients’ adverse transfusion reaction and pre-transfusion C reactive protein (CRP) level and EO% (percentage of eosinophils) .
Methods
2
The observation group was chosen from among sixty-six young patients who experienced transfusion-related adverse events between January 2019 and December 2020. For each patient chosen to be included in the observation group, another patient from the same department, with the same disease and gender, who had been hospitalized in the same month and received the same type of blood product transfusion, but had not experienced any transfusion-related adverse effects, was chosen to be in the control group. We examined and compared their ages, transfusion experiences, allergy backgrounds, EO%, and CRP levels in peripheral blood prior to transfusion. A receiver operating characteristic (ROC) curve was used to examine the diagnostic value of EO% and CRP for transfusion-related adverse events. Simultaneously, a logistic analysis was performed on the risk factors for transfusion-related adverse events.
Results
2
Pre-transfusion CRP was higher in patients with FNHTR in the observation group than it was in patients in the control group; pre-transfusion CRP was also higher in patients with ATR in the observation group than it was in patients in the control group. There were also statistically significant differences between these variables in the percentage of patients with transfusion history and pre-transfusion EO% (
P
<0.05). For the transfusion of different blood types, there was statistical significance in the occurrence of ATR and FNHTR (
P
<0.05). For the diagnosis of FNHTR, the CRP area under the ROC curve was 0.889, and the best cut-off value was 18.05 mg/L. For the diagnosis of ATR, the area under the ROC curve was 0.749, and the best cut-off values were 17.60 mg/L.
Conclusion
2
Pre-transfusion C-reactive protein level is an independent risk factor for FNHTR and ATR in young patients; the predictive value of EO% for adverse blood transfusion reactions is insufficient.
青年人输血不良反应嗜酸性粒细胞百分比C反应蛋白危险因素
young peopleadverse transfusion reactionEO%C reactive proteinrisk factors
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