PANoptosis： Molecular Mechanism of Action and Effects on Blinding Eye Diseases

LI Qing-qing; LIU Lian

doi:10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2023.0405

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PANoptosis： Molecular Mechanism of Action and Effects on Blinding Eye Diseases

Review | 更新时间：2024-02-19

- PANoptosis： Molecular Mechanism of Action and Effects on Blinding Eye Diseases
- Journal of Sun Yat-sen University(Medical Sciences) Vol. 44, Issue 4, Pages: 576-581(2023)
- 作者机构：
  
  暨南大学附属第一医院眼科，广东广州 510630
- 作者简介：
  
  LIU Lian；E-mail： liulianbb@163.com
- 基金信息：
- DOI：10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2023.0405
  CLC： R77
- Published：20 July 2023，
  
  Received：15 March 2023，
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李青青,刘莲.PANoptosis 的分子作用机制及其在致盲性眼病中的作用[J].中山大学学报（医学科学版）,2023,44(04):576-581.

LI Qing-qing,LIU Lian.PANoptosis： Molecular Mechanism of Action and Effects on Blinding Eye Diseases[J].Journal of Sun Yat-sen University(Medical Sciences),2023,44(04):576-581.
李青青,刘莲.PANoptosis 的分子作用机制及其在致盲性眼病中的作用[J].中山大学学报（医学科学版）,2023,44(04):576-581. DOI： 10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2023.0405.

LI Qing-qing,LIU Lian.PANoptosis： Molecular Mechanism of Action and Effects on Blinding Eye Diseases[J].Journal of Sun Yat-sen University(Medical Sciences),2023,44(04):576-581. DOI： 10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2023.0405.

摘要

以往研究认为各种细胞死亡途径有其独特的调控机制，近年来随着对细胞死亡途径的进一步研究发现各种途径之间存在串扰和协调，进而有研究提出一种新的细胞死亡途径：PANoptosis，认为PANoptosis是由PANoptosome复合物调节的炎症性程序性细胞死亡途径，具有细胞焦亡、细胞凋亡和/或坏死性凋亡的关键特征，并不能被细胞焦亡、细胞凋亡、坏死性凋亡中任意一种死亡方式单独表征。特定的触发因素如病毒、细菌及真菌感染可以诱导宿主以PANoptosis的途径死亡。本文就PANoptosis的相关通路、调节剂以及在致盲性眼病中的潜在作用进行相关综述。

Abstract

Previous studies focused on the unique regulatory mechanisms of different cell death pathways. However， recent studies highlight crosstalk and co-ordination between these pathways and initiate a new cell death process called PANoptosis （pyroptosis， apoptosis， necroptosis）. PANoptosis is an inflammatory programmed cell death pathway regulated by the PANoptosome complex with critical features of pyroptosis， and/or necroptosis but cannot be characterized by any of the death modes of pyroptosis， apoptosis or necroptosis alone. By activating the PANoptosis pathway， some triggers like bacterial， viral， and fungal infections can cause death of the host. This review explains the PANoptosis-related routes， regulators and their potential effects on blinding eye diseases.

关键词

泛凋亡凋亡坏死性凋亡焦亡致盲性眼病

Keywords

PANoptosisapoptosisnecroptosispyroptosisblinding eye diseases

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Related Institution

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School of Public Health， Sun Yat-sen University

School of Public Health， Sun Yat-sen University （Shenzhen Campus）

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