Roles of Long Noncoding RNAs and Glycolysis in Digestive System Tumors

HOU Xin-rui; WANG Xiao-ping

doi:10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2023.0407

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Roles of Long Noncoding RNAs and Glycolysis in Digestive System Tumors

Review | 更新时间：2024-02-19

- Roles of Long Noncoding RNAs and Glycolysis in Digestive System Tumors
- Journal of Sun Yat-sen University(Medical Sciences) Vol. 44, Issue 4, Pages: 587-595(2023)
- 作者机构：
  
  西藏民族大学医学院高原低氧环境与生命健康实验室，陕西咸阳 712082
- 作者简介：
  
  WANG Xiao-ping， E-mail： xpwang@xzmu.edu.cn
- 基金信息：
- DOI：10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2023.0407
  CLC： R735
- Published：20 July 2023，
  
  Received：07 March 2023，
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侯鑫睿,王小平.lncRNA与糖酵解在消化道肿瘤中的作用[J].中山大学学报（医学科学版）,2023,44(04):587-595.

HOU Xin-rui,WANG Xiao-ping.Roles of Long Noncoding RNAs and Glycolysis in Digestive System Tumors[J].Journal of Sun Yat-sen University(Medical Sciences),2023,44(04):587-595.
侯鑫睿,王小平.lncRNA与糖酵解在消化道肿瘤中的作用[J].中山大学学报（医学科学版）,2023,44(04):587-595. DOI： 10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2023.0407.

HOU Xin-rui,WANG Xiao-ping.Roles of Long Noncoding RNAs and Glycolysis in Digestive System Tumors[J].Journal of Sun Yat-sen University(Medical Sciences),2023,44(04):587-595. DOI： 10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2023.0407.

摘要

长链非编码RNA是一类长度大于200个碱基的非编码RNA，广泛参与多种肿瘤的起始、进展和糖酵解过程，可作为竞争内源性RNA海绵吸收miRNA，通过抑制miRNA的表达进而调控肿瘤细胞的糖酵解，影响细胞的增殖、侵袭等活性。lncRNA还可以通过调控一系列糖酵解酶和信号通路中的信号分子达到对肿瘤糖酵解的调节作用进而影响细胞的恶性生物学活性，此外，消化道肿瘤是具有代表性的一类恶性肿瘤，我们通过探讨lncRNA与糖酵解在消化道肿瘤中的作用，以及lncRNA在肿瘤诊断、治疗及预后方面的效果，为肿瘤的防治研究与临床应用提供新理论依据。lncRNA有望成为肿瘤发生的新候选基因并作为其肿瘤生物标志物，为降低消化道肿瘤及其他肿瘤的发病率及死亡率提供新思路。

Abstract

Long noncoding RNAs （LncRNAs）， a class of noncoding RNAs greater than 200 bases in length， are widely involved in the initiation， progression and glycolytic processes of many tumors， and can act as competitive endogenous RNA sponges to absorb miRNAs. LncRNAs can also inhibit miRNA expression， thereby regulate the glycolysis of tumor cells， affects cell proliferation， invasion and other biological activities. This review explores the roles of LncRNAs and glycolysis in digestive system tumors （DST）， a representative group of malignant tumors. Extending the LncRNA role in the diagnosis， treatment and prognosis of other tumors， we conclude that LncRNAs have the potential to be new candidate genes for tumorigenesis and serve as tumor biomarkers， which provides new insight into morbidity and mortality decrease of DST and other tumors.

关键词

消化道肿瘤长链非编码RNA糖酵解生物标志物治疗

Keywords

digestive system tumor （DST）long noncoding RNAs （LncRNAs）glycolysisbiomarkerstherapy

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