Changes of Macular Microcirculation After Near Work in Myopic Patients

ZHANG Ru-ting; TENG Yue; LI Jun-hui; LIAN Li-hua

doi:10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2023.0419

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Changes of Macular Microcirculation After Near Work in Myopic Patients

Clinical Research | 更新时间：2024-02-19

- Changes of Macular Microcirculation After Near Work in Myopic Patients
- Journal of Sun Yat-sen University(Medical Sciences) Vol. 44, Issue 4, Pages: 684-690(2023)
- 作者机构：
  
  1.中南大学爱尔眼科学院爱尔眼科研究所湖南长沙 410000
  2.广州中医药大学第一附属医院，广东广州 510000
- 作者简介：
  
  LIAN Li-hua； E-mail： lianlihua5047@gzucm.edu.cn
- 基金信息：
- DOI：10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2023.0419
  CLC： R771
- Published：20 July 2023，
  
  Received：29 August 2022，
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张汝婷,滕月,李君慧等.近视患者近距离用眼后黄斑血流的变化[J].中山大学学报（医学科学版）,2023,44(04):684-690.

ZHANG Ru-ting,TENG Yue,LI Jun-hui,et al.Changes of Macular Microcirculation After Near Work in Myopic Patients[J].Journal of Sun Yat-sen University(Medical Sciences),2023,44(04):684-690.
张汝婷,滕月,李君慧等.近视患者近距离用眼后黄斑血流的变化[J].中山大学学报（医学科学版）,2023,44(04):684-690. DOI： 10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2023.0419.

ZHANG Ru-ting,TENG Yue,LI Jun-hui,et al.Changes of Macular Microcirculation After Near Work in Myopic Patients[J].Journal of Sun Yat-sen University(Medical Sciences),2023,44(04):684-690. DOI： 10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2023.0419.

摘要

目的

比较近距离用眼前后黄斑区浅层视网膜微循环指标的变化，探讨近距离用眼影响近视的可能原因。

方法

采用近距离观看手机视频1 h作为近距离用眼的方式，通过光学相干断层扫描血管成像（OCTA）技术测量用眼前、后黄斑区6 mm × 6 mm范围内的浅层视网膜微循环指标，包括浅层（神经纤维层至外丛状层内界）视网膜血管长度密度（VLD）、血管灌注密度（VPD）以及黄斑中心凹无灌注区（FAZ）的面积（FAZ-A）、周长（FAZ-P）、形态指数（FAZ-CI），按区域划分为中心、内层、外层及整体，得出11项微循环指标，对比用眼前及用眼后各项指标的差异。

结果

近距离用眼后的黄斑区浅层视网膜微循环指标普遍较用眼前低，除了FAZ-A及FAZ-P以外（

= 0.148、

= 0.975），差异均具有统计学意义，VLD中以中心VLD（差异1.00）及内层VLD（差异0.80）的差异最大（

= 0.001、

= 0.008），VPD中以中心VPD（差异0.02）及内层VPD（差异0.02）最大（

= 0.001、

= 0.008），不同屈光度及眼轴的青年变化程度无差异。

结论

近距离用眼可能通过影响黄斑区浅层视网膜微循环的改变，导致局部缺血缺氧，影响近视的发生及发展。

Abstract

Objective

To compare the changes of retinal microcirculation indexes in the anterior and posterior macular areas of the eyes used at close range and to explore the possible causes of myopia affected by near work.

Methods

Watching mobile phone video for 1 hour at close range was used as the method of defining near work. The OCTA technology was used to measure the superficial retinal microcirculation indexes within 6 by 6 mm macular area before and after near work， including the superficial retinal VLD from the nerve fiber layer to the inner boundary of the outer plexiform layer， the VPD， nonperfusion area of FAZ， FAZ-P and FAZ circulation，. The FAZ was divided int center， inner layer， outer layer and overall according to the region， and 11 microcirculation indexes were obtained to compare the differences between before and after near work.

Results

The indexes of superficial retinal microcirculation in the macular area generally decreased after near work， except for FAZ-A and FAZ-P（

= 0.148， 0.975）. The largest differences among both VLD and VPD occurred between the central and inner layer（Difference = 1.00， 0.80， 0.02， 0.02，

= 0.001， 0.008， 0.001， 0.008）. No differences in microcirculation indexs were observed in the macular area after near work with different diopters and axial lengths.

Conclusion

Near work may affect the occurrence and development of myopia by affecting the changes of retinal microcirculation in the superficial layer of macula， leading to ischemia and hypoxia.

关键词

近距离用眼黄斑区浅层视网膜微循环近视

Keywords

near workmicrocirculation in macular areamyopia

references

Holden BA， Fricke TR， Wilson DA， et al. Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050［J］. Ophthalmology， 2016， 123（5）： 1036-1042.

French AN， Morgan IG， Burlutsky G， et al. Prevalence and 5- to 6-year incidence and progression of myopia and hyperopia in Australian schoolchildre［J］. Ophthalmology， 2013， 120（7）： 1482-1491.

Naidoo KS， Fricke TR， Frick KD， et al. Potential lost productivity resulting from the global burden of myopia： systematic review， meta-analysis， and modeling［J］. Ophthalmology， 2019， 126（3）： 338-346.

Li M， Yang Y， Jiang H， et al. Retinal microvascular network and microcirculation assessments in high myopia［J］. Am J Ophthalmol， 2017， 174：56-67.

Al-Sheikh M， Phasukkijwatana N， Dolz-Marco R， et al. Quantitative OCT angiography of the retinal microvasculature and the choriocapillaris in myopic eyes［J］. Invest Ophthalmol Vis Sci， 2017， 58（4）： 2063-2069.

王丹阳，谭倩，秦嘉敏，等.学龄儿童眼球后极部脉络膜厚度及相关因素分析［J］. 中山大学学报（医学科学版）， 2020， 41（1）： 103-111.

Wang DY， Tan Q， Qin JM， et al. Observation on choroidal thickness of school-aged children and relevant factors［J］. J Sun Yat-sen Univ （Med.Sci）， 2020，41（1）： 103-111.

Shail G， Lisa AO. A systematic review of near work and myopia： measurement， relationships， mechanisms and clinical corollaries［J］. Acta Ophthalmol， 2022， 100（4）： 376-387.

McCrann S， Loughman J， Butler JS， et al. Smartphone use as a possible risk factor for myopia［J］. Clin Exp Optom， 2021， 104（1）： 35-41.

Morgan IG， French AN， Ashby RS， et al．The epidemics of myopia： aetiology and prevention l［J］. Prog Retin Eye Res， 2018， 62： 134-149．

Hansen MH， Laigaard PP， Olsen EM， et al. Low physical activity and higher use of screen devices are associated with myopia at the age of 16-17 years in the CCC2000 eye study［J］. Acta Ophthalmol， 2020， 98（3）： 315-321.

Enthoven CA， Tideman JWL， Polling JR， et al. The impact of computer use on myopia development in childhood： the generation R study［J］. Prev Med. 2020， 132： 105988.

Yao L， Qi LS， Wang XF， et al. Refractive change and incidence of myopia among a group of highly selected senior high school students in China： a prospective study in an aviation cadet prerecruitment class［J］. Invest Ophthalmol Vis Sci， 2019， 60（5）： 1344-1352.

Wu H， Chen W， Zhao F， et al. Scleral hypoxia is a target for myopia control［J］. Proc Natl Acad Sci USA， 2018， 115（30）： E7091-E7100.

Zhang S， Zhang G， Zhou X， et al. Changes in choroidal thickness and choroidal blood perfusion in guinea pig myopia［J］. Invest Ophthalmol Vis Sci， 2019， 60（8）： 3074-3083.

Zhou X， Zhang S， Zhang G， et al. Increased choroidal blood perfusion can inhibit form deprivation myopia in guinea pigs［J］. Invest Ophthalmol Vis Sci， 2020， 61（13）： 25.

Yang Y， Wang JH， Jiang H， et al. Retinal microvasculature alteration in high myopia［J］. Invest Ophthalmol Vis Sci， 2016， 57（14）： 6020-6030.

Zhao F， Zhang D， Zhou Q， et al. Scleral HIF-1α is a prominent regulatory candidate for genetic and environmental interactions in human myopia pathogenesis［J］. EBioMedicine， 2020， 57： 102878.

范圆媛，谢平，胡仔仲. OCT测量黄斑区神经节细胞复合体厚度在高度近视眼中的应用进展［J］. 眼科学报， 2023， 38（3）： 274-286.

Fan YY， Xie P， Hu ZZ. Application progress of OCT measurement for ganglion cell complex thickness in high myopic eyes［J］. Eye Sci， 2023， 38（3）： 274-286.

Summers JA. The choroid as a sclera growth regulator［J］. Exp Eye Res， 2013， 114： 120-127.

Xiang XQ， Luo LY， Tang M， et al. Application of optical coherence tomography angiography in children with anisometropic amblyopia［J］. J Shanghai Jiaotong Univ （Med Sci）， 2019， 39（1）： 79-83.

Li KJ， Yu XB， Dai H. The alterations of microvascular structure in branch retinal vein occlusion eyes before and after anti-vascular endothelial growth factor drug therapy［J］. Chin J Ocul Fundus Dis， 2019， 35（1）： 25-30.

Sambhav K， Grover S， Chalam KV. The application of optical coherence tomography angiography in retinal diseases［J］. Surv Ophthalmol， 2017， 62（6）： 838-866.

Richter GM， Chang R， Situ B， et al. Diagnostic performance of macular versus peripapillary vessel parameters by optical coherence tomography angiography for glaucoma［J］. Transl Vis Sci Technol， 2018， 7（6）： 21.

田春柳，赵军，张娟美，等. 基于OCTA的高度近视患眼黄斑区视网膜血管密度分析［J］.眼科新进展， 2020， 40（3）： 257-260.

Tian CL， Zhao J， Zhang JM， et al. Analysis of retinal vascular density in macular area of eyes with high myopia by OCTA ［J］. Recent Adv Ophthalmol， 2020， 40（3）： 257-260.

王丽雯，崔林，邹吉新，等. OCTA在视网膜静脉阻塞诊疗中的应用价值［J］.国际眼科杂志， 2019， 19（8）： 1361-1364.

Wang LW， Cui L， Zou JX， et al. Application value of OCTA examination in diagnosis and treatment of retinal vein occlusion［J］. Int Eye Sci， 2019， 19（8）： 1361-1364.

Shoji T， Ishii H， Kanno J， et al. Distance between the center of the FAZ measured automatically and the highest foveal bulge using OCT-angiography in elderly healthy eyes［J］. Sci Rep， 2021， 11（1）： 21485.

曾俊，刘陇黔. OCTA对青少年近视人群视网膜微血管密度的观察［J］.中华眼视光学与视觉科学杂志， 2020， 22（5）： 354-359.

Zeng J， Liu LQ. Retinal vessel density in adolescent myopia based on OCTA： an observational study［J］. Chin J Optom Ophthalmol Vis Sci， 2020， 22（5）： 354-359.

邵伊润，毛剑波，沈丽君，等. 高度近视继发脉络膜新生血管和单纯高度近视患眼以及正常眼黄斑区血流参数对比观察［J］.中华眼底病杂志， 2019， 35（5）： 446-450.

Shao YR， Mao JB， Shen LJ， et al. The comparison of macular blood flow parameters in myopic choroidal neovascularization， high myopia and normal people［J］. Chin J Ocular Fundus Dis， 2019， 35（5）： 446-450.

瞿佳，李瑾. 近视眼发生和发展机制研究的新进展［J］.中华眼科杂志， 2021， 57（4）： 311-314.

Qu J， Li J. New progress in the mechanism of myopia occurrence and development［J］. Chin J Ophthalmol， 2021， 57（4）： 311-314.

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