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广州医科大学附属广州市妇女儿童医疗中心,广东 广州 510623
HU Dan-dan; E-mail: guohdd@126.com
Published:20 November 2023,
Received:04 July 2023,
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朱俐燕,胡丹丹.胆汁酸影响乙肝疫苗免疫应答的研究进展[J].中山大学学报(医学科学版),2023,44(06):910-914.
ZHU Li-yan,HU Dan-dan.Research Progress on the Influence of Bile Acids on the Immune Response of Hepatitis B Vaccine[J].Journal of Sun Yat-sen University(Medical Sciences),2023,44(06):910-914.
朱俐燕,胡丹丹.胆汁酸影响乙肝疫苗免疫应答的研究进展[J].中山大学学报(医学科学版),2023,44(06):910-914. DOI: 10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2023.0603.
ZHU Li-yan,HU Dan-dan.Research Progress on the Influence of Bile Acids on the Immune Response of Hepatitis B Vaccine[J].Journal of Sun Yat-sen University(Medical Sciences),2023,44(06):910-914. DOI: 10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2023.0603.
接种乙型肝炎疫苗(HepB)是预防乙型肝炎病毒(HBV)感染最安全、有效的手段。HepB无应答受多种因素影响,解决接种HepB后的免疫应答不良问题对控制HBV感染具有重要意义。胆汁酸对人体免疫调节发挥重要作用,胆汁酸是否对HepB免疫应答产生影响,目前尚无确切研究。本文就胆汁酸与HepB免疫应答之间相关性进行综述,为进一步明确胆汁酸在疫苗免疫的发病机制及免疫预防提供参考。
Hepatitis B vaccine (HepB) vaccination is the safest and most effective means of preventing hepatitis B virus (HBV) infection. HepB non-response is influenced by multiple factors, and solving the problem of poor immune response after HepB vaccination is of great significance for controlling HBV infection. Bile acids play an important role in human immune regulation, and whether bile acids have an effect on the HepB immune response has not been definitively studied. This article reviews the correlation between bile acids and HepB immune response, and provides a reference for further clarifying the pathogenesis and immunoprevention of bile acids in vaccine immunity.
胆汁酸乙型肝炎疫苗免疫应答T淋巴细胞干扰素白细胞介素
bile acidshepatitis B vaccineimmune responseT-lymphocyteinterferonterleukin
Liu J, Fei Y, Zhou T, et al. Bile acids impair vaccine response in children with biliary atresia[J]. Front Immunol, 2021, 12: 642546.
Fawaz R, Baumann U, Ekong U, et al. Guideline for the evaluation of cholestatic jaundice in infants: Joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition[J]. J Pediatr Gastroenterol Nutr, 2017,64(1): 154-168.
Johnston A, Ponzetti K, Anwer MS, et al. cAMP-guanine exchange factor protection from bile acid-induced hepatocyte apoptosis involves glycogen synthase kinase regulation of c-Jun NH 2 -terminal kinase[J]. Am J Physiol Gastrointest Liver Physiol, 2011, 301(2): G385-G400.
谢新宝. 特殊健康状态儿童预防接种专家共识之二十二——儿童肝病与预防接种[J].中国实用儿科杂志, 2019, 34(7): 537-538.
Xie XB. Expert consensus No. 22 on vaccination for children with special health status - Liver disease and vaccination in children[J]. Chin J Pract Pediatr, 2019, 34(7): 537-538.
刘一锋, 凡小丽, 沈怡, 等. 原发性胆汁性胆管炎治疗应答的影响因素及预后预测作用研究[J]. 四川大学学报(医学版), 2023, 54(5): 930-936.
Liu YF, Fan XL, Shen Y, et al. Response to primary biliary cholangitis treatment: influencing factors and the role inprognosis prediction[J]. J Sichuan Univ(Med Sci), 2023, 54(5): 930-936.
Yang Y, Zhang J. Bile acid metabolism and circadian rhythms[J]. Am J Physiol Gastrointest Liver Physiol, 2020, 319(5): G549-G563.
Fiorucci S, Carino A, Baldoni M, et al. Bile acid signaling in inflammatory bowel diseases[J/OL]. Dig Dis Sci, 2021, 66(3): 674-693.
Chiang JYL. Bile acids: regulation of synthesis[J]. J Lipid Res, 2009, 50(10): 1955-1966.
Saco TV, Strauss AT, Ledford DK. Hepatitis B vaccine nonresponders: possible mechanisms and solutions[J]. Ann Allergy Asthma Immunol, 2018, 121(3): 320-327.
Romano' L, Zanetti AR. Hepatitis B vaccination: a historical overview with a focus on the Italian achievements[J]. Viruses, 2022, 14(7): 1515.
Zhang L, Jiang T, Yang Y, et al. ostpartum hepatitis and host immunity in pregnant women with chronic HBV infection[J]. Front Immunol, 2023, 13: 1112234.
Nakayama T, Hirahara K, Onodera A, et al. Th2 cells in health and disease[J]. Annu Rev Immunol, 2017, 35: 53-84.
许长涛,郑方,王瑞官,等.胆管结石性黄疸患者围术期内调节性T细胞免疫功能变化临床研究[J]. 临床军医杂志, 2018, 46(8): 865-868.
Xu CT, Zheng F, Wang RG, et al. Immunological changes of regulatory T cells during perioperative period in patients with cholangiolitic jaundice[J]. Clin J Med Off, 2018, 46(8): 865-868.
Damo M, Joshi NS. Treg cell IL-10 and IL-35 exhaust CD8+T cells in tumors[J]. Nat Immunol, 2019, 20(6): 674-675.
Frimpong-Boateng K, van Rooijen N, Geiben-Lynn R. Regulatory T cells suppress natural killer cells during plasmid DNA vaccination in mice, blunting the CD8+ T cell immune response by the cytokine TGFbeta[J]. PLoS One, 2010, 5(8): e12281.
Chuang CM, Hoory T, Monie A, et al. Enhancing therapeutic HPV DNA vaccine potency through depletion of CD4+CD25+ T regulatory cells[J]. Vaccine, 2009, 27(5): 684-689.
Jack AD, Hall AJ, Maine N, et al. What level of hepatitis B antibody is protective[J]. J Infect Dis, 1999, 179(2): 489-492.
Pattyn J, Hendrickx G, Vorsters A, et al. Hepatitis B vaccines[J]. J Infect Dis, 2021, 224(12 Suppl 2): S343-S351.
Beulens C, Raven SFH, van Jaarsveld CHM, et al. Evaluation of a personalized, dose-sparing revaccination strategy in hepatitis B vaccine non-responders[J]. Vaccine, 2022, 40(23): 3210-3215.
Filippelli M, Lionetti E, Gennaro A, et al. Hepatitis B vaccine by intradermal route in non responder patients: an update[J]. World J Gastroenterol, 2014, 20(30): 10383-10394.
Fonzo M, Nicolli A, Maso S, et al. Body mass index and antibody persistence after measles, mumps, rubella and hepatitis B vaccinations[J]. Vaccines (Basel), 2022, 10(7): 1152.
Sausen DG, Shechter O, Bietsch W, et al. Hepatitis B and hepatitis D viruses: a comprehensive update with an immunological focus[J]. Int J Mol Sci, 2022, 23(24): 15973.
Sjogren MH. Prevention of hepatitis B in nonresponders to initial hepatitis B virus vaccination[J]. Am J Med, 2005, 118 Suppl 10A: 34S-39S.
Velu V, Saravanan S, Nandakumar S, et al. Relationship between T-lymphocyte cytokine levels and sero-response to hepatitis B vaccines[J]. World J Gastroenterol, 2008,14(22):3534-3540.
马越, 许立新, 汪健, 等. Th1/Th2细胞相关因子对乙肝疫苗免疫效果的影响[J]. 中国国境卫生检疫杂志, 2019, 42(6): 437-439.
Ma Y, Xu LX, Wang J, et al. Effects of Th1/Th2 related cytokines on hepatitis B immunization[J]. Chin J Front Health Quar, 2019, 42(6): 437-439.
Doedée AM, Kannegieter N, Öztürk K, et al. Higher numbers of memory B-cells and Th2-cytokine skewing in high responders to hepatitis B vaccination[J]. Vaccine, 2016, 34(19): 2281-2289.
王维伟, 王麟, 朱雄伟, 等. 乙型肝炎疫苗不同接种方案对肝移植受者接种成功率及Th2细胞变化的影响[J]. 中国疫苗和免疫, 2017, 23(2): 144-147.
Wang WW, Wang L, Zhu XW, et al. Impact of different hepatitis B vaccine immunization schedules on immune seroconversion and Th2 cell changes among liver transplantation recipients[J]. Chin J Vacc Immun, 2017, 23(2): 144-147.
Yang Z, Wang L, Niu W, et al. Increased CD4+CD25+FoxP3+ regulatory T cells in the blood of nonresponders after standard hepatitis B surface antigen vaccine immunization[J]. Clin Immunol, 2008, 127(2): 265-266.
Garner-Spitzer E, Wagner A, Paulke-Korinek M, et al. Tick-borne encephalitis (TBE) and hepatitis B nonresponders feature different immunologic mechanisms in response to TBE and influenza vaccination with involvement of regulatory T and B cells and IL-10[J]. J Immunol, 2013, 191(5): 2426-2436.
Pols TWH, Puchner T, Korkmaz HI, et al. Lithocholic acid controls adaptive immune responses by inhibition of Th1 activation through the Vitamin D receptor[J]. PLoS One, 2017, 12(5): e0176715.
Ichikawa R, Takayama T, Yoneno K, et al. Bile acids induce monocyte differentiation toward interleukin-12 hypo-producing dendritic cells via a TGR5-dependent pathway[J]. Immunology, 2012, 136(2): 153-162.
Schroder K, Hertzog PJ, Ravasi T, et al. Interferon-gamma: an overview of signals, mechanisms and functions[J]. J Leukoc Biol, 2004, 75(2): 163-189.
Hettwer J, Hinterdobler J, Miritsch B, et al. Interleukin-1β suppression dampens inflammatory leucocyte production and uptake in atherosclerosis[J]. Cardiovasc Res, 2022, 118(13): 2778-2791.
李嘉铃, 姜露, 杨庆利, 等. Th1和Th2细胞因子的基因多态性与新生儿乙型肝炎疫苗低免疫应答的关联性研究[J]. 中国疫苗和免疫, 2020, 26(3): 253-260.
Li JL, Jiang L, Yang QL, et al. Association of Th1 and Th2 cytokine gene polymorphisms with low immune response to hepatitis B vaccine in newborns[J]. Chin J Vacc Immun, 2020, 26(3): 253-260.
Guo C, Xie S, Chi Z, et al. Bile acids control inflammation and metabolic disorder through inhibition of NLRP3 inflammasome[J]. Immunity, 2016, 45(4): 802-816.
Hunter CA, Jones SA. IL-6 as a keystone cytokine in health and disease[J]. Nat Immunol, 2015, 16(5): 448-457.
Lv L, Chen Z, Bai W, et al. Taurohyodeoxycholic acid alleviates trinitrobenzene sulfonic acid induced ulcerative colitis via regulating Th1/Th2 and Th17/Treg cells balance[J]. Life Sci, 2023, 318: 121501.
Read KA, Jones DM, Pokhrel S, et al. Aiolos represses CD4+T cell cytotoxic programming via reciprocal regulation of Tfh transcription factors and IL-2 sensitivity[J]. Nat Commun, 2023, 14(1): 1652.
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