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Relationship between Helicobacter Pylori and Male Infertility
- Journal of Sun Yat-sen University(Medical Sciences) Vol. 44, Issue 4, Pages: 601-606(2023)
- 作者机构：
1.贵州医科大学附属医院泌尿外科，贵阳 550001
2.贵州省黔南州人民医院泌尿外科，都匀 558000
3.贵州医科大学临床医学院，贵阳 550001
- 作者简介：
WU Zhi-ping； E-mail： gzwzp@foxmail.com
- 基金信息：
DOI：10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).20230712.001
CLC： R698+.2Published：20 July 2023，
Received：07 November 2022，
扫 描 看 全 文
刘晋阳,吴志平.幽门螺杆菌与男性不育的关系[J].中山大学学报（医学科学版）,2023,44(04):601-606.
LIU Jin-yang,WU Zhi-ping.Relationship between Helicobacter Pylori and Male Infertility[J].Journal of Sun Yat-sen University(Medical Sciences),2023,44(04):601-606.
刘晋阳,吴志平.幽门螺杆菌与男性不育的关系[J].中山大学学报（医学科学版）,2023,44(04):601-606. DOI： 10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).20230712.001.
LIU Jin-yang,WU Zhi-ping.Relationship between Helicobacter Pylori and Male Infertility[J].Journal of Sun Yat-sen University(Medical Sciences),2023,44(04):601-606. DOI： 10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).20230712.001.
摘要
幽门螺杆菌（Hp）是一种革兰阴性、螺旋型杆菌，是目前医学所知唯一能在胃中生活的细菌，在人群中的感染率较高。幽门螺杆菌与消化性溃疡、慢性胃炎等疾病有着密切的关系，近几年还发现幽门螺杆菌与许多胃外疾病也有关联，甚至与男性不育都有关。由于男性因素所导致的不孕不育的发生率逐年上升，且其中有一部分仍病因不明，为了进一步讨论幽门螺杆菌与不育的关系，本文总结了国外近几年关于幽门螺杆菌和不育的研究，旨在推测和探讨二者之间可能的关系。
Abstract
Helicobacter pylori
（
H.pylori
） is a gram-negative， spiral-shaped bacillus and it is the only bacteria known in medicine that can live in the stomach， with a high infection rate in the population. Besides its confirmed link to peptic ulcer and chronic gastritis，
H.pylori
has recently been found to be associated with many extragastric diseases， including male infertility. The incidence of male factor infertility keeps rising， but some reasons remain unclear. This paper summarized the research on
H.pylori
and infertility abroad in recent years in order to speculate and explore the possible relationship between them.
关键词
幽门螺杆菌胃外疾病男性不育
Keywords
Helicobacter pylori （H. pylori）extragastric diseasesmale infertility
references
Ding SZ， Du YQ， Lu H， et al. Chinese consensus report on family-based helicobacter pylori infection control and management（2021 Edition）［R］. Gut， 2022， 71（2）： 238-253.
Sun Y， Zhang J. Helicobacter pylori recrudescence and its influencing factors［J］. J Cell Mol Med， 2019， 23（12）： 7919-7925.
He J， Liu Y， Ouyang Q， et al. Helicobacter pylori and unignorable extragastric diseases： mechanism and implications［J］. Front Microbiol， 2022， 13： 972777.
World Health Organization. International classification of diseases 11th revision［S］. Geneva： World Health Organization， 2018.
Agarwal A， Baskaran S， Parekh N， et al. Male infertility［J］. Lancet， 2021， 397（10271）： 319-333.
El-Garem Y， El-Sawy M， Mostafa T. Seminal helicobacter pylori treatment improves sperm motility in infertile asthenozoospermic men［J］. Urology， 2014， 84（6）： 1347-1350.
Moretti E， Figura N， Campagna MS， et al. Infectious burden and semen parameters［J］. Urology， 2017， 100： 90-96.
Chehab M， Madala A， Trussell JC. On-label and off-label drugs used in the treatment of male infertility［J］. Fertil Steril， 2015， 103（3）： 595-604.
Björndahl L， Kirkman Brown J； other Editorial Board Members of the WHO Laboratory Manual for the Examination and Processing of Human Semen. The sixth edition of the WHO Laboratory Manual for the Examination and Processing of Human Semen： ensuring quality and standardization in basic examination of human ejaculates［J］. Fertil Steril， 2022， 117（2）： 246-251.
Villaverde AISB， Netherton J， Baker MA. From past to present： the link between reactive oxygen species in sperm and male infertility［J］. Antioxidants （Basel）， 2019， 8（12）： 616.
Sun H， Gong TT， Jiang YT， et al. Global， regional， and national prevalence and disability-adjusted life-years for infertility in 195 countries and territories， 1990-2017： results from a global burden of disease study， 2017［J］. Aging， 2019， 11（23）： 10952-10991.
Ding N， Zhang X， Zhang XD， et al. Impairment of spermatogenesis and sperm motility by the high-fat diet-induced dysbiosis of gut microbes［J］. Gut， 2020， 69（9）： 1608-1619.
Wang F， Liu W， Jiang Q， et al. Lipopolysaccharide-induced testicular dysfunction and epididymitis in mice： a critical role of tumor necrosis factor alpha［J］. Biol Reprod， 2019， 100（3）： 849-861.
Zhang P， Feng Y， Li L， et al. Improvement in sperm quality and spermatogenesis following faecal microbiota transplantation from alginate oligosaccharide dosed mice［J］. Gut， 2021， 70（1）： 222-225.
Zhang T， Sun P， Geng Q， et al. Disrupted spermatogenesis in a metabolic syndrome model： the role of vitamin A metabolism in the gut-testis axis［J］. Gut， 2022， 71（1）： 78-87.
Yang L， Zhang J， Xu J， et al. Helicobacter pylori infection aggravates dysbiosis of gut microbiome in children with gastritis［J］. Front Cell Infect Microbiol， 2019， 9： 375.
Parsons BN， Ijaz UZ， D'Amore R， et al. Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of helicobacter pylori-induced atrophic gastritis， autoimmune atrophic gastritis and proton pump inhibitor use［J］. PLoS Pathog， 2017， 13（11）： e1006653.
Jones TA， Hernandez DZ， Wong ZC， et al. The bacterial virulence factor CagA induces microbial dysbiosis that contributes to excessive epithelial cell proliferation in the drosophila gut［J］. PLoS Pathog， 2017， 13（10）： e1006631.
Wang L， Yao H， Tong T， et al. Dynamic changes in antibiotic resistance genes and gut microbiota after helicobacter pylori eradication therapies［J］. Helicobacter， 2022， 27（2）： e12871.
Zhou Y， Ye Z， Wang Y， et al. Long-term changes in the gut microbiota after triple therapy， sequential therapy， bismuth quadruple therapy and concomitant therapy for helicobacter pylori eradication in Chinese children［J］. Helicobacter， 2021， 26（4）： e12809.
Cao R， Xu Y， Weng Z， et al. Metal-organic-framework-based hydrogen-release platform for multieffective helicobacter pylori targeting therapy and intestinal flora protective capabilities［J］. Adv Mater， 2022， 34（2）： e2105738.
Olekhnovich EI， Manolov AI， Samoilov AE， et al. Shifts in the human gut microbiota structure caused by quadruple helicobacter pylori eradication therapy［J］. Front Microbiol， 2019， 10： 1902.
Hao Y， Feng Y， Yan X， et al. Gut microbiota-testis axis： FMT improves systemic and testicular micro-environment to increase semen quality in type 1 diabetes［J］. Mol Med， 2022， 28（1）： 45.
Ji J， Yang H. Using probiotics as supplementation for helicobacter pylori antibiotic therapy［J］. Int J Mol Sci， 2020， 21（3）： 1136.
Schooling CM， Dowd JB， Jones HE. Helicobacter pylori is associated with lower androgen activity among men in NHANES III［J］. Gut， 2013， 62（9）： 1384-1385.
Liu JM， Wu CT， Hsu RJ， et al. Association between helicobacter pylori infection and mortality risk in prostate cancer patients receiving androgen deprivation therapy： a real-world evidence study［J］. Cancer Med， 2021， 10（22）： 8162-8171.
Song X， Cai C， Jin Q， et al. The efficacy of helicobacter pylori eradication in diabetics and its effect on glycemic control： a systematic review and meta-analysis［J］. Helicobacter， 2021， 26（2）： e12781.
Mansori K， Moradi Y， Naderpour S， et al. Helicobacter pylori infection as a risk factor for diabetes： a meta-analysis of case-control studies［J］. BMC Gastroenterol， 2020， 20（1）： 77.
Azami M， Baradaran HR， Dehghanbanadaki H， et al. Association of helicobacter pylori infection with the risk of metabolic syndrome and insulin resistance： an updated systematic review and meta-analysis［J］. Diabetol Metab Syndr， 2021， 13（1）： 145.
Dhindsa S， Ghanim H， Batra M， et al. Hypogonadotropic hypogonadism in men with diabesity［J］. Diabetes Care， 2018， 41（7）： 1516-1525.
Zhong O， Ji L， Wang J， et al. Association of diabetes and obesity with sperm parameters and testosterone levels： a meta-analysis［J］. Diabetol Metab Syndr， 2021， 13（1）： 109.
Baccetti B， La Marca A， Piomboni P， et al. Insulin-dependent diabetes in men is associated with hypothalamo-pituitary derangement and with impairment in semen quality［J］. Hum Reprod， 2002， 17（10）： 2673-2677.
Wang S， Zhang K， Yao Y， et al. Bacterial infections affect male fertility： a focus on the oxidative stress-autophagy axis［J］. Front Cell Dev Biol， 2021， 9： 727812.
Strycharz J， Rygielska Z， Swiderska E， et al. SIRT1 as a therapeutic target in diabetic complications［J］. Curr Med Chem， 2018， 25（9）： 1002-1035.
Youssefi M， Tafaghodi M， Farsiani H， et al. Helicobacter pylori infection and autoimmune diseases； Is there an association with systemic lupus erythematosus， rheumatoid arthritis， autoimmune atrophy gastritis and autoimmune pancreatitis？ a systematic review and meta-analysis study［J］. J Microbiol Immunol Infect， 2021， 54（3）： 359-369.
Figura N， Piomboni P， Ponzetto A， et al. Helicobacter pylori infection and infertility［J］. Eur J Gastroenterol Hepatol， 2002， 14（6）： 663-669.
Ponzetto A， Holton J. Extragastric diseases correlated with helicobacter pylori［J］. Helicobacter， 2019， 24（1）： e12549.
Feng C， Lv PP， Huang CC， et al. Sperm parameters and anti-Müllerian hormone remain stable with helicobacter pylori infection： a cross-sectional study［J］. BMC Urol， 2020， 20（1）： 188.
Vitale SG， Ferrari F， Ciebiera M， et al. The role of genital tract microbiome in fertility： a systematic review［J］. Int J Mol Sci， 2021， 23（1）： 180.
Sánchez-Alonzo K， Matamala-Valdés L， Parra-Sepúlveda C， et al. Intracellular presence of helicobacter pylori and its virulence-associated genotypes within the vaginal yeast of term pregnant women［J］. Microorganisms， 2021， 9（1）： 131.
Hiengrach P， Panpetch W， Chindamporn A， et al. Helicobacter pylori， protected from antibiotics and stresses inside Candida albicans vacuoles， cause gastritis in mice［J］. Int J Mol Sci， 2022， 23（15）： 8568.
Head S. Helicobacter pylori infection： a sexually transmitted disease？［J］. BMJ， 2008， 337： a2077.
Sgambato D， Visciola G， Ferrante E， et al. Prevalence of helicobacter pylori infection in sexual partners of H. pylori-infected subjects： role of gastroesophageal reflux［J］. United European Gastroenterol J， 2018， 6（10）： 1470-1476.
Lespessailles E， Toumi H. Proton pump inhibitors and bone health： an update narrative review［J］. Int J Mol Sci， 2022， 23（18）： 10733.
Abrahami D， McDonald EG， Schnitzer ME， et al. Proton pump inhibitors and risk of colorectal cancer［J］. Gut， 2022， 71（1）： 111-118.
Favia M， Gerbino A， Notario E， et al. The non-gastric H+/K+ ATPase （ATP12A） is expressed in mammalian spermatozoa［J］. Int J Mol Sci， 2022， 23（3）： 1048.
Wang G， Guo Y， Zhou T， et al. In-depth proteomic analysis of the human sperm reveals complex protein compositions［J］. J Proteomics， 2013， 79： 114-122.
Cooray A， Kim JH， Chae MR， et al. Perspectives on potential fatty acid modulations of motility associated human sperm ion channels［J］. Int J Mol Sci， 2022， 23（7）： 3718.
Escoffier J， Arnaud B， Kaba M， et al. Pantoprazole， a proton-pump inhibitor， impairs human sperm motility and capacitation in vitro［J］. Andrology， 2020， 8（6）： 1795-1804.
Kumar A， Kumar R， Flanagan J， et al. Esomeprazole reduces sperm motility index by targeting the spermic cholinergic machinery： a mechanistic study for the association between use of proton pump inhibitors and reduced sperm motility index［J］. Biochem Pharmacol， 2020， 182： 114212.
Hou L， Fu Y， Zhao C， et al. Ciprofloxacin and enrofloxacin can cause reproductive toxicity via endocrine signaling pathways［J］. Ecotoxicol Environ Saf， 2022， 244： 114049.
Karaman M， Budak H， Çiftci M. Amoxicillin and gentamicin antibiotics treatment adversely influence the fertility and morphology through decreasing the Dazl gene expression level and increasing the oxidative stress［J］. Arch Physiol Biochem， 2019， 125（5）： 447-455.
Hassan MH， Awadalla EA， Ali RA， et al. Thiamine deficiency and oxidative stress induced by prolonged metronidazole therapy can explain its side effects of neurotoxicity and infertility in experimental animals： effect of grapefruit co-therapy［J］. Hum Exp Toxicol， 2020， 39（6）： 834-847.
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