Research Progress on Mechanisms of Triggeringreceptor Expressed on Myeloid Cells-2 in Cognitive Dysfunction

SHI Limin; XU Ping

doi:10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).20240004.018

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Research Progress on Mechanisms of Triggeringreceptor Expressed on Myeloid Cells-2 in Cognitive Dysfunction

Review | 更新时间：2024-02-22

- Research Progress on Mechanisms of Triggeringreceptor Expressed on Myeloid Cells-2 in Cognitive Dysfunction
- Journal of Sun Yat-sen University(Medical Sciences) Vol. 45, Issue 1, Pages: 7-12(2024)
- 作者机构：
  
  遵义医科大学附属医院神经内科，贵州，遵义，563000
- 作者简介：
  
  XU Ping； E-mail： xuping527@vip.sina.com
- 基金信息：
- DOI：10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).20240004.018
  CLC： R741.02
- Published：20 January 2024，
  
  Received：10 September 2023，
  
  Accepted：01 December 2023
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师利敏,徐平.髓系细胞触发受体２在认知功能障碍中相关机制的研究进展[J].中山大学学报（医学科学版）,2024,45(01):7-12.

SHI Limin,XU Ping.Research Progress on Mechanisms of Triggeringreceptor Expressed on Myeloid Cells-2 in Cognitive Dysfunction[J].Journal of Sun Yat-sen University(Medical Sciences),2024,45(01):7-12.
师利敏,徐平.髓系细胞触发受体２在认知功能障碍中相关机制的研究进展[J].中山大学学报（医学科学版）,2024,45(01):7-12. DOI： 10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).20240004.018.

SHI Limin,XU Ping.Research Progress on Mechanisms of Triggeringreceptor Expressed on Myeloid Cells-2 in Cognitive Dysfunction[J].Journal of Sun Yat-sen University(Medical Sciences),2024,45(01):7-12. DOI： 10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).20240004.018.

摘要

神经免疫系统对中枢神经系统的发育、衰老和损伤至关重要，逐渐成为人们研究的热点。髓系细胞触发受体２（TREM2）是免疫球蛋白超家族的一种跨膜受体，在中枢神经系统中主要表达于小胶质细胞。越来越多的研究表明，靶向TREM2对改善阿尔兹海默症、血管性痴呆、帕金森病、术后认知功能障碍、肥胖等疾病相关的认知功能障碍有很大的潜力。然而，其在认知功能障碍中的具体作用尚缺乏系统性的总结。故本文综述了TREM2在认知功能障碍中相关机制的最新研究进展，以期为认知功能障碍的治疗提供新的靶点。

Abstract

The neuroimmune system is crucial for the development， aging， and damage of the central nervous system， and has gradually become a research hotspot. Triggeringreceptor expressed on myeloid cells-2 （TREM2） is a transmembrane receptor of the immunoglobulin superfamily and is mainly expressed in the microglia in the central nervous system. An increasing number of studies indicate that TREM2 has great potential to improve cognitive dysfunction related to Alzheimer's disease， vascular dementia， Parkinson's disease， postoperative cognitive impairment， obesity， etc. However， there is a lack of a systematic summary of the specific role of TREM2 in cognitive dysfunction. This paper reviews the progress in the latest research on the related mechanisms of TREM2 in cognitive dysfunction， in order to provide new strategies for the treatment of cognitive dysfunction.

关键词

认知功能障碍TREM2阿尔茨海默病血管性痴呆帕金森病术后认知功能障碍肥胖

Keywords

cognitive dysfunctiontriggeringreceptor expressed on myeloid cells-2 （TREM2）Alzheimer's diseasevascular dementiaParkinson's diseasepostoperative cognitive impairmentobesity

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Related Institution

Department of Physiology of School of Basic Medicine， Chongqing Medical University

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School of Life Science and Engineering， Southwest Jiaotong University

Institute of Clinical Laboratory， The First Affiliated Hospital， University of South China

Institute of Neurology， The First Affiliated Hospital， University of South China

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