Effect and Mechanism of N-acetylcysteine in Ischemic Stroke

YANG Chen; WAN Wenhui

doi:10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2024.0203

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Effect and Mechanism of N-acetylcysteine in Ischemic Stroke

Review | 更新时间：2024-04-15

- Effect and Mechanism of N-acetylcysteine in Ischemic Stroke
- Journal of Sun Yat-sen University(Medical Sciences) Vol. 45, Issue 2, Pages: 190-195(2024)
- 作者机构：
  
  中国人民解放军东部战区总医院干部病房一科，江苏南京 210002
- 作者简介：
  
  WAN Wenhui； E-mail：wanwhnj@163.com
- 基金信息：
- DOI：10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2024.0203
  CLC： R743.33
- Published：20 March 2024，
  
  Received：13 December 2023，
  
  Accepted：08 March 2024
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杨晨,万文辉.N-乙酰半胱氨酸在缺血性脑卒中的作用及机制[J].中山大学学报（医学科学版）,2024,45(02):190-195.

YANG Chen,WAN Wenhui.Effect and Mechanism of N-acetylcysteine in Ischemic Stroke[J].Journal of Sun Yat-sen University(Medical Sciences),2024,45(02):190-195.
杨晨,万文辉.N-乙酰半胱氨酸在缺血性脑卒中的作用及机制[J].中山大学学报（医学科学版）,2024,45(02):190-195. DOI： 10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2024.0203.

YANG Chen,WAN Wenhui.Effect and Mechanism of N-acetylcysteine in Ischemic Stroke[J].Journal of Sun Yat-sen University(Medical Sciences),2024,45(02):190-195. DOI： 10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2024.0203.

摘要

缺血性脑卒中（CIS）是指因脑部血液循环障碍，缺血、缺氧所致的局限性脑组织的缺血性坏死或软化，其发病率在脑血管病中占据首位。氧气和营养供应的减少会导致神经元的严重丧失，并导致中风患者脑功能的缺陷。开发缺血性脑卒中的治疗方法仍然是临床医学的重要挑战。抗氧化剂N-乙酰半胱氨酸（NAC）是谷胱甘肽前体物质，缺血性脑卒中动物模型及一些临床研究的证据表明，NAC可以有效地保护大脑免受缺血损伤。本文从抗氧化、抑制炎症、保护脑神经和线粒体功能、稳定动脉斑块及溶栓功能等多方面阐述NAC在CIS中的作用机制，旨在从基础层面深入探究NAC与CIS的关系，为NAC进一步应用于缺血性脑卒中患者的防治提供理论依据。

Abstract

Ischemic stroke （CIS） refers to ischemic necrosis or softening of localized brain tissue caused by cerebral blood circulation disorders， ischemia and hypoxia. The incidence of CIS is the highest among cerebrovascular diseases. Reduced supply of oxygen and nutrients leads to severe loss of neurons and deficits in brain function in stroke patients. Developing treatments for ischemic stroke remains an important challenge in clinical medicine. The antioxidant N-acetylcysteine （NAC） is a precursor of glutathione， and evidence from animal models of ischemic stroke and some clinical studies suggest that NAC can effectively protect the brain from ischemic damage. In this paper， the mechanism of NAC in CIS is described from various aspects， such as anti-oxidation， inhibition of inflammation， protection of cerebral nerve and mitochondrial function， stabilization of arterial plaque and thrombolytic function， aiming to explore the relationship between NAC and CIS in depth from the basic level， and to provide a theoretical basis for the further application of NAC in the prevention and treatment of patients with ischemic stroke.

关键词

N-乙酰半胱氨酸缺血性脑卒中氧化应激炎症溶栓

Keywords

N-acetylcysteineischemic strokeoxidative stressinflammationthrombolysis

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