Differentiation of Pure Mucinous Carcinoma and Fibroadenoma on Ultrasound of the Breast

WANG Hongli; HU Yue; TAN Cui; GU Ran; MEI Jingsi; YU Yuexing; CHEN Lili; GONG Chang

doi:10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.20240617.006

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Differentiation of Pure Mucinous Carcinoma and Fibroadenoma on Ultrasound of the Breast

Clinical Research | 更新时间：2024-07-30

- Differentiation of Pure Mucinous Carcinoma and Fibroadenoma on Ultrasound of the Breast
- Journal of Sun Yat-sen University(Medical Sciences) Vol. 45, Issue 4, Pages: 631-636(2024)
- 作者机构：
  
  中山大学孙逸仙纪念医院乳腺肿瘤中心 // 广东省恶性肿瘤表观遗传与基因调控重点实验室，粤港RNA医学联合实验室，广东广州 510120
- 作者简介：
  
  CHEN Lili； E-mail： Chenlli@mail.sysu.edu.cn
  GONG Chang； E-mail： gchang@mail.sysu.edu.cn
- 基金信息：
- DOI：10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.20240617.006
  CLC： R445.1
- Published：20 July 2024，
  
  Received：28 May 2024，
  
  Accepted：13 June 2024
- 稿件说明：
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王红莉,胡越,谭翠等.超声对乳腺单纯黏液癌与纤维腺瘤鉴别诊断的价值[J].中山大学学报（医学科学版）,2024,45(04):631-636.

WANG Hongli,HU Yue,TAN Cui,et al.Differentiation of Pure Mucinous Carcinoma and Fibroadenoma on Ultrasound of the Breast[J].Journal of Sun Yat-sen University(Medical Sciences),2024,45(04):631-636.
王红莉,胡越,谭翠等.超声对乳腺单纯黏液癌与纤维腺瘤鉴别诊断的价值[J].中山大学学报（医学科学版）,2024,45(04):631-636. DOI： 10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.20240617.006.

WANG Hongli,HU Yue,TAN Cui,et al.Differentiation of Pure Mucinous Carcinoma and Fibroadenoma on Ultrasound of the Breast[J].Journal of Sun Yat-sen University(Medical Sciences),2024,45(04):631-636. DOI： 10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.20240617.006.

摘要

目的

探讨乳腺单纯黏液癌（PMC）和纤维腺瘤（FA）的超声表现差异，为临床鉴别诊断提供参考。

方法

回顾性搜集2012年1月至2021年1月间在中山大学孙逸仙纪念医院就诊的连续乳腺PMC初诊患者50例及2018年6月至2019年1月间的连续乳腺FA初诊患者100例超声资料。依据2013年版乳腺影像报告与数据系统（BI-RADS）评估两组病变的超声图像特征，并比较两组患者年龄、病变的长径及超声图像特征的差异。

结果

PMC患者中位年龄为47岁，而FA为33岁，PMC患者年龄较FA偏大，两者差异具有统计学意义（

0.001）。PMC患者病变中位长径2.4 cm大于FA的1.8 cm，差异有统计学意义（

=0.001）。PMC中，70% （35/50）表现为不规则形， 82%（41/50）与皮肤平行， 92%（46/50）边缘不清晰， 72%（36/50）内部呈低回声， 68%（34/50）后方回声增强；FA中，69%（69/100）表现为卵圆形或圆形，98%（98/100）与皮肤平行，54%（54/100）边缘清晰，98%（98/100）内部呈低回声，75%（75/100）后方回声未见变化，PMC与FA相应超声表现的差异有统计学意义（

0.001，

=0.001，

0.001，

0.001），而病变内是否存在钙化、病变的血流表现在两者间差异无统计学意义。

结论

与FA相比，PMC患者年龄及病变长径偏大，并且在超声上，大部分乳腺PMC的形态及边缘仍表现为浸润性癌的生长特点，同时，PMC的后方回声增强，是其独特的表现。

Abstract

Objective

To investigate the difference of ultrasound characteristics between pure mucinous carcinoma （PMC） and fibroadenoma （FA） of the breast.

Methods

Ultrasound data of 50 continuous patients with breast PMC from January 2012 to January 2021 and 100 continuous patients with breast FA from June 2018 to January 2019 in Sun Yat-sen Memorial Hospital of Sun Yat-sen University were retrospectively reviewed. The ultrasound characteristics of the two groups were evaluated according to the 2013 BI-RADS Ultrasound Atlas， and the differences in age， maximum diameter and ultrasound characteristics between the two groups were compared.

Results

The median age of PMC patients was 47 years and that of FA patients was 33 years. The age of PMC patients was higher than that of the FA group， and the difference between the two groups of patients was statistically significant （

0.001）. The median maximum diameter of PMC patients was 2.4 cm， which was greater than that of the FA group （1.8 cm）， and the difference was statistically significant （

=0.001）. Of the PMC， 70% （35/50） were irregular， 82% （41/50） were parallel to the skin， 92% （46/50） had no circumscribed margin， 72% （36/50） were hypoechoic， and 68% （34/50） had enhanced posterior echo. Of the FA， 69% （69/100） were oval or round， 98% （98/100） were parallel to the skin， 54% （54/100） had circumscribed margin， 98% （98/100） were hypoechoic， and 75% （75/100） had no posterior features. The differences in the above ultrasound characteristics between the PMC and FA groups were statistically significant （

0.001，

=0.001，

0.001，

0.001）. There was no significant difference between calcifications and blood flow.

Conclusions

Compared with the FA group， patients with PMC are older and the diameter of the lesions are larger. On ultrasound， the morphology and margin of most breast PMC still show the growth characteristics of invasive cancer. Meanwhile， the posterior echo of PMC is enhanced， which is a unique manifestation.

关键词

乳腺黏液癌单纯黏液癌纤维腺瘤超声

Keywords

breastmucinous carcinomapure mucinous carcinomafibroadenomaultrasound

references

Di Saverio S， Gutierrez J， Avisar E. A retrospective review with long term follow up of 11，400 cases of pure mucinous breast carcinoma［J］. Breast Cancer Res Treat， 2008， 111（3）： 541-547.

Barkley CR， Ligibel JA， Wong JS， et al. Mucinous breast carcinoma： a large contemporary series［J］. Am J Surg， 2008， 196（4）： 549-551.

Wang H， Zha H， Du Y， et al. An integrated radiomics nomogram based on conventional ultrasound improves discriminability between fibroadenoma and pure mucinous carcinoma in breast［J］. Front Oncol， 2023， 13： 1170729.

张伟，王娟，梁汝娜，等. 探讨不同病理类型乳腺黏液癌的多模态超声表现［J］. 中国超声医学杂志， 2022， 38（3）： 274-277.

Zhang W， Wang J， Liang NN， et al. Exploring the multimodal ultrasonic manifestations of different pathological types of breast mucinous carcinoma［J］. Chin J Ultrasound Med， 2022， 38（3）： 274-277.

Liang T， Shen J， Zhang S， et al. Using ultrasound-based multilayer perceptron to differentiate early breast mucinous cancer and its subtypes from fibroadenoma［J］. Front Oncol， 2021， 11： 724656.

Kaoku S， Konishi E， Fujimoto Y， et al. Sonographic and pathologic image analysis of pure mucinous carcinoma of the breast［J］. Ultrasound Med Biol， 2013， 39（7）： 1158-1167.

Tan JZ， Waugh J， Kumar B， et al. Mucinous carcinomas of the breast： imaging features and potential for misdiagnosis［J］. J Med Imaging Radiat Oncol， 2013， 57（1）： 25-31.

Bode MK， Rissanen T. Imaging findings and accuracy of core needle biopsy in mucinous carcinoma of the breast［J］. Acta Radiol， 2011， 52（2）： 128-133.

Ferre R， Aldis A， Alsharif S， et al. Differentiation of fibroadenomas and pure mucinous carcinomas on dynamic contrast-enhanced MRI of the breast using volume segmentation for kinetic analysis： a feasibility study［J］. AJR Am J Roentgenol， 2016， 206（2）： 253-258.

曲宁，罗娅红. 基于DCE-MRI列线图鉴别乳腺单纯型黏液癌与T2WI明显高信号纤维腺瘤［J］. 肿瘤影像学， 2024， 33（1）： 31-38.

Qu N， Luo YH. Development of a nomogram for differentiation between pure mucinous breast carcinomas and fibroadenomas based on DCE-MRI features［J］. Oncoradiology， 2024， 33（1）： 31-38.

杜亮，崔凤，周长玉，等. 乳腺单纯型黏液癌与T2高信号纤维腺瘤的MRI对比研究［J］. 医学影像学杂志， 2022， 32（11）： 1918-1922.

Du L， Cui F， Zhou CY， et al. MR comparative study of simple mucinous carcinoma of the breast and T2 hyperintensity fibroadenoma［J］. J Med Imaging， 2022， 32（11）： 1918-1922.

巩海燕，聂晨蕾，杜丽雯，等. 超声鉴别诊断乳腺黏液癌与纤维腺瘤的价值［J］. 医学研究杂志， 2022， 51（7）： 53-55； +60.

Gong HY， Nie CL， Du LW， et al. Ultrasonographic differentiation of mucinous breast carcinoma and fibroadenoma ［J］. J Med Res， 2022， 51（7）： 53-55； +60.

Mendelson E， Böhm-Vélez M， Berg W， et al. ACR BI-RADS ultrasound. ACR BI-RADS Atlas， Breast Imaging Reporting and Data System 5th ed Reston［M］. American College of Radiology， 2013.

徐玲，王殊. 乳腺纤维腺瘤的诊断与治疗［J］. 中华乳腺病杂志（电子版）， 2014，8（2）：88-91.

Xu L， Wang S. Diagnosis and treatment of breast fibroadenoma［J］. Chin J Breast Dis （Elect Edi）， 2014， 8（2）： 88-91.

孙可欣，郑荣寿，顾秀瑛，等. 2000—2014年中国肿瘤登记地区女性乳腺癌发病趋势及年龄变化情况分析［J］. 中华预防医学杂志， 2018， 52（6）： 567-572.

Sun KX， Zheng RS， Gu XY， et al. Incidence trend and change in the age distribution of female breast cancer in cancer registration areas of China from 2000 to 2014［J］. Chin J Prev Med， 2018， 52（6）： 567-572.

Desantis CE， Ma J， Gaudet MM， et al. Breast cancer statistics， 2019［J］. CA Cancer J Clin， 2019， 69（6）： 438-451.

智文祥，常才，陈敏，等. 乳腺单纯黏液腺癌大小对超声特征及诊断准确性的影响［J］. 中华超声影像学杂志， 2015， 24（6）： 515-518.

Zhi WX， Chang C， Chen M， et al. Influence of size on sonographic characteristics of pure mucinous carcinoma of the breast and diagnostic accuracy［J］. Chin J Ultrasonogr， 2015， 24（6）： 515-518.

Lam WW， Chu WC， Tse GM， et al. Sonographic appearance of mucinous carcinoma of the breast［J］. AJR Am J Roentgenol， 2004， 182（4）： 1069-1074.

Zhang H， Qiu L， Peng Y. The sonographic findings of micropapillary pattern in pure mucinous carcinoma of the breast［J］. World J Surg Oncol， 2018， 16（1）： 151.

蒋南，曹军英. 不同细胞外黏液含量的乳腺单纯黏液癌的超声特征［J］. 中国医学影像学杂志， 2023， 31（5）： 476-479.

Jiang N， Cao JY. Ultrasonographic features of different extracellular mucus content in pure mucinous breast carcinoma［J］. Chin J Med Imag， 2023， 31（5）： 476-479.

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Related Author

GONG Chang

WANG Hongli

HU Yue

TAN Cui

GU Ran

YU Yuexing

CHEN Lili

MEI Jingsi

Related Institution

Breast Tumor Center， Sun Yat-sen Memorial Hospital， Sun Yat-sen University // Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation， Guangdong-Hong Kong Joint Laboratory for RNA Medicine， Guang Dong Guangzhou

Breast Tumor Center，Sun Yat-sen Memorial Hospital

Department of Ultrasound，Guangdong Key Laboratory of Liver Disease Research，The Third Affiliated Hospital of Sun Yat-senUniversity

Longgang District Central Hospital of Shenzhen

Department of Pathology，Zhongshan Boai Hospital

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